Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion.

Similarly to the first human case, lung tissue concentrations of DOX exhibited a decreasing trend throughout the procedure reaching the levels of 30, 18 and 28 μg/g for the upper, middle, and lower areas of the lung, respectively 30 min post blood reperfusion.

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