IL-10 and TGF-β Induced Arginase Expression Contributes to Deficient Nitric Oxide Response in Human Visceral Leishmaniasis.

post-treatment), statistically effective pairing for the samples was observed (Spearman rs=0.8031; p<0.0001) and plasma samples from treated patients showed highly significant reduction of arginase activity (36.46 ± 17.17 vs. 17.72 ± 6.201 mU/ml; p=0.0001) ( Figure 3B ).

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Interestingly, PBMCs with VL plasma neutralized for IL-10 alone also produced marginally higher nitrite level which was borderline significant (13.3 ± 3.653 vs. 11.3 ± 5.908 μM; p=0.0474) ( Figure 4D ).

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