Phasic oxygen dynamics confounds fast choline-sensitive biosensor signals in the brain of behaving rodents.

Noteworthy, in the low-KmO 2 app group, the highest COA peak was achieved in response to the second O 2 addition (10 μM of cumulative [O 2 ]) rather than to the first in six out of seven calibrations (marginally significant difference between 5 and 10 μM O 2 responses, p=0.076, paired t -test).

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The result revealed a decreasing trend ( Figure 3F ), suggesting that biosensors with a high enzyme loading have low sensitivity to tonic O 2 changes (low-KmO 2 app ).

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