We observed that co-formulation of ruxolitinib with saRNA did not have any effect on the percentage of EGFP + cells ( Figure 4 C), although there was a slight trend that increasing the dose of ruxolitinib actually decreased the percentage of EGFP + cells from ∼8% to ∼5%.
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Innate Inhibiting Proteins Enhance Expression and Immunogenicity of Self-Amplifying RNA.
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