Decrease in treatment intensity predicts worse outcome in patients with locally advanced head and neck squamous cell carcinoma undergoing radiochemotherapy.

Overall, RCT was associated with a highly significant decline in kidney function (median eGFR at baseline: 94.7 ml/min/1.73m 2 ) and did not fully recover over the first 12 weeks after treatment initiation ( n = 1542 estimated glomerular filtration rate (eGFR) records, mean records per patient: 8.4, Fig. 2 ).

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