Extended half-life factor VIII concentrates in adults with hemophilia A: Comparative pharmacokinetics of two products.

15 The utility of personalized PK was shown in a small Spanish study of 21 individuals with hemophilia A treated with Advate, in which the adoption of PK‐guided prophylactic regimens using MyPKFit led to a tendency to fewer spontaneous bleeds, and abolished the highly significant correlation between individual half‐life values and joint bleeds that had existed in the retrospective period before implementation of PK guidance. 16 Overall median FVIII consumption increased modestly by 4.4% in the year following PK‐guided therapy compared to the year before.

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The difference in V ss just failed to reach statistical significance.

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