Pyk2 overexpression in postsynaptic neurons blocks amyloid β<sub>1-42</sub>-induced synaptotoxicity in microfluidic co-cultures.

Consistent with the RNAseq data, we observed a decreasing trend in Pyk2 total protein levels and an increasing trend in the p-Pyk2 protein levels in the brains of Alzheimer’s patients compared to healthy controls ( Supplementary Fig. 9 ).

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