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Circ_DOCK1 regulates USP11 through miR-132-3p to control colorectal cancer progression.

World J Surg Oncol · 2021 · PMC7941900 · PMID 33685455

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a decreasing trendno p-value reported
The incidence has a decreasing trend in highly developed countries, while it is predictive to increase to 2–5 million new cases in 2035 [ 1 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.