Emetine suppresses SARS-CoV-2 replication by inhibiting interaction of viral mRNA with eIF4E.

However, a highly significant reduction in the levels of SARS-CoV-2 total RNA ( Fig. 2 a) as well as mRNA ( Fig. 2 a) was observed in emetine-treated cells as compared to vehicle control-treated cells which suggested that emetine could affect viral genome synthesis in the target cells.

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