So, it might be significant that Mapuskar noted a superoxide-driven difference in radiosensitivity in human fibroblasts the age of cell donors, and that avasopasem reverses that sensitivity. 48 Importantly, a paper by El-Mahdy et al reported avasopasem’s concurrent ability to protect normal epithelial cells, while sensitizing
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Superoxide Dismutase as an Intervention for Radiation Therapy-Associated Toxicities: Review and Profile of Avasopasem Manganese as a Treatment Option for Radiation-Induced Mucositis.
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