Cost-Effectiveness of Direct Non-Vitamin K Oral Anticoagulants Versus Vitamin K Antagonists for the Management of Patients with Non-Valvular Atrial Fibrillation Based on Available "Real-World" Evidence: The Italian National Health System Perspective.

Several studies suggested an increasing trend in the prevalence and incidence of AF in the last decades; that course could partially be explained by the aging population and the increasing prevalence of co-morbidities and cardiovascular risk factors, in addition to other factors such as lifestyle changes and improved diagnosis [ 1 , 3 ].

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