MEK1/2 activity modulates TREM2 cell surface recruitment.

J Biol Chem · 2021 · PMC7948395 · PMID 33839686

Europe PMC DOI

hedged sentence

—

closest p

—

boldest claim

The sentences

may be significantno p-value reported

Still, considering that heterozygous mutations show intermediate effects, and the possibility that common variant carriers have diminished TREM2 function by unknown mechanisms, it is reasonable to speculate that increased TREM2 activity above baseline may be beneficial, and that the approximately twofold increase in cell surface TREM2 that we observed with MEK inhibition may be significant.

also in 13,097 other papers

Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.