Inhibiting Th1/2 cells influences hepatic capillarization by adjusting sinusoidal endothelial fenestrae through Rho-ROCK-myosin pathway.

Through observation for 7 consecutive weeks, we found that secretion of IFN-γ, the signature cytokine of Th1 cells, showed an increasing trend in the anti-VAP-1 group and on the 3 rd week after injection, it increased to a significant high level; however, a decreasing trend was observed in the anti-integrin α4 group and the level decreased to a significant low value at the 3 rd week after injection.

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