A study on multi-organ dysfunction syndrome in malaria using sequential organ failure assessment score.

Most malaria cases were seen in the African Region (213 million or 93%), followed by the South-East Asian Region (3.4%).[ 1 ] In India, malaria cases have consistently declined from 2.08 million in 2001 to about 4 lakhs in 2018.[ 2 ] Infection with malaria parasites may result in a wide variety of symptoms, ranging from absent or very mild symptoms to severe disease and even death.[ 3 ] There is an increasing trend for multiple organ dysfunctions attributed to Plasmodium falciparum as well as Plasmodium vivax .[ 4 , 5 , 6 , 7 ] Cerebral malaria, renal dysfunction, severe anemia, acute respiratory distress syndrome (ARDS), shock, hemoglobinuria, thrombocytopenia, hypoglycemia, and multiple organ involvement are the major reported complications of this infection in India[ 8 , 9 ] as well as in other countries.[ 10 ] The WHO criteria[ 11 ] are the standard criteria used for defining the severity of malaria.

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