Clinical impact of rebiopsy among patients with epidermal growth factor receptor-mutant lung adenocarcinoma in a real-world clinical setting.

22 , 23 In a previous meta‐analysis of 22 studies that included NSCLC patients with or without EGFR mutations, the presence of an EGFR mutation was associated with a markedly higher incidence of subsequent brain metastasis and an increasing trend in the incidence of initial brain metastasis. 22 Another study with 212 NSCLC patients reported that T790M mutation was more common in patients with brain metastasis ( n = 12/40, 30%, p < 0.01). 23 Presently, the duration from initial biopsy to rebiopsy was significantly longer in patients without brain metastasis than in patients with brain metastasis (median 15 vs. 19 months, p = 0.003).

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