Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice.

Additional NAFLD-specific phenotypes, such as inflammation and hepatocellular ballooning 31 , did not differ significantly between treatment groups in the samples analyzed, although there was a slight trend toward improved inflammation scores in the WD/LD-T group relative to the WD/WD-V group (Supplementary Table S2 ).

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