Genomic Space of <i>MGMT</i> in Human Glioma Revisited: Novel Motifs, Regulatory RNAs, NRF1, 2, and CTCF Involvement in Gene Expression.

Int J Mol Sci · 2021 · PMC7958331 · PMID 33801310

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highly significantno p-value reported

In this context, the abundant presence of RNA regulatory elements in the form of micro RNAs, antisense, and LncRNAs within the MGMT and the immediately adjacent EBF2 genes is highly significant and the discovery opens up a new area of investigations relevant to MGMT expression in cancer pathophysiology, drug resistance and treatment of gliomas and other cancer types.

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