Genetic Predictors of Chemotherapy-Induced Peripheral Neuropathy from Paclitaxel, Carboplatin and Oxaliplatin: NCCTG/Alliance N08C1, N08CA and N08CB Study.

Cancers (Basel) · 2021 · PMC7959452 · PMID 33802509

Europe PMC DOI

hedged sentences

0.0000

closest p · 0.0× alpha

0.0600

boldest claim

The sentences

marginal significancep < 1.0 × 10 −6actually significant

Two SNPs on chromosome 5 and eight other SNPs on chromosome 12 were also associated with CIPN at a marginal significance level of p < 1.0 × 10 −6 .

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borderline significantp = 0.06so close (0.05 < p ≤ 0.1)

Furthermore, genetic ancestry, specifically African American ancestry, was also significantly associated with CIPN change from baseline (CE = −7.63, SE = 2.43, and p < 0.002) with an overall significance of p = 0.007, while sex was only borderline significant (CE = 3.29, SE = 1.77, and p = 0.06), Table 2 .

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