Musashi-2 (MSI2) regulates epidermal growth factor receptor (EGFR) expression and response to EGFR inhibitors in EGFR-mutated non-small cell lung cancer (NSCLC).

Oncogenesis · 2021 · PMC7961039 · PMID 33723247

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borderline significantno p-value reported

mRNA expression of EGFR individual cell lines responded to MSI2 depletion in distinct ways, including increased expression (344SQ), borderline significant decreased expression (A549 and HCC827), and no change (PC9, H1650); there was no consistent pattern across models that could explain the invariant decrease in EGFR protein and activity levels.

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