S100A11 (calgizzarin) is released via NETosis in rheumatoid arthritis (RA) and stimulates IL-6 and TNF secretion by neutrophils.

Sci Rep · 2021 · PMC7966750 · PMID 33727634

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may be significantno p-value reported

Finally, we can speculate that the pro-inflammatory effect of S100A11 on neutrophils may be significant only at the onset of RA before the chronic infammation develops.

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