Combined genomic and proteomic approaches reveal DNA binding sites and interaction partners of TBX2 in the developing lung.

First, our motif analysis found a highly significant enrichment of DNA sequences similar to a T-box binding element initially identified in an in vitro binding site selection approach for the prototypical T-box protein Brachyury and to a consensus sequence previously identified by ChIP-Seq for TBX2 in neuroblastoma cell lines [ 53 , 54 ].

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