Understanding the origin of COVID-19 requires to change the paradigm on zoonotic emergence from the spillover to the circulation model.

Infect Genet Evol · 2021 · PMC7969828 · PMID 33744401

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might not be significantno p-value reported

This indicates that the genome is highly mutated and that the linear mutation/time relationship on which molecular clock analyses are based is no longer linear and might not be significant ( Frutos et al., 2021 ). 3.

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