Pharmacologic management of nocturnal polyuria: a contemporary assessment of efficacy, safety, and progress toward individualized treatment.

reported that diclofenac 50 mg tablets taken nightly by 26 adult patients with nocturia (⩾2 nightly voids) due to nocturnal polyuria conferred significant benefit compared with placebo, with nocturia frequency improving from 2.7 to 2.3 voids ( p < 0.004) and nocturnal polyuria index improving from 0.44 to 0.39 ( p < 0.001), as well as borderline significance observed for nocturnal urine volume (802–745 ml, p = 0.05). 126 Notably, the significant shift in 24-h urine production toward the daytime period (i.e., decreased nocturnal polyuria index) is consistent with well-controlled physiologic evidence on the effect of diclofenac on renal function, charact

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