Changes of antibiotic prescribing pattern and its resistance to E. Coli in South Korea: a 12-year retrospective observational study.

However, we noted an increasing trend of cefotaxime prescription in hospitals (τ = 0.94, p < 0.01), LTCFs (τ = 0.55, p = 0.02) and clinics (τ = 1.0, p < 0.01).

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We observed a decreasing trend of fluoroquinolone prescription in hospitals (τ = − 0.52, p = 0.02) and clinics (τ = − 0.94, p < 0.01) (Fig. 1 , Supplementary Table 1 ).

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