The MRI probe Gd-Hyd which targets allysine was previously shown to be effective and specific for identifying liver fibrogenesis in a 12 week CCl 4 disease model, with a highly significant increase in MR signal in the fibrotic liver tissue compared to control animals, that tracked with hydroxyproline concentration 36 .
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Quantitative, noninvasive MRI characterization of disease progression in a mouse model of non-alcoholic steatohepatitis.
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