IL-12p40/IL-23p40 Blockade With Ustekinumab Decreases the Synovial Inflammatory Infiltrate Through Modulation of Multiple Signaling Pathways Including MAPK-ERK and Wnt.

Looking further downstream, we found no significant differences for the pro-inflammatory cytokines IL-6 or IL-8, only mRNA levels of MMP3, showed a borderline significant decrease at week 12 ( p = 0.047) ( Figure 2A ).

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