Metabolic and behavioral features of acute hyperpurinergia and the maternal immune activation mouse model of autism spectrum disorder.

PLoS One · 2021 · PMC7971557 · PMID 33735311

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likely to be significantno p-value reported

However, based on the known effects of reactive oxygen species, ATP, and other purinergic effectors on the microbiome [ 24 ], vagus nerve [ 152 ], adrenal function [ 153 ], and even hypothalamic function [ 154 ] via circumventricular organs that lack a blood brain barrier [ 155 ], these synergistic multi-system effects are likely to be significant.

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