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Effect of S-1 on blood levels of phenobarbital and phenytoin: A case report.

Clin Case Rep · 2021 · PMC7981613 · PMID 33768879

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an increasing trendno p-value reported
As expected, plasma levels of PHT tended to increase with the initiation of S‐1, but PB also showed an increasing trend.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.