Human placental mesenchymal stem cells ameliorate chemotherapy-induced damage in the testis by reducing apoptosis/oxidative stress and promoting autophagy.

Finally, the levels of antioxidant enzymes such as SOD and CAT recovered and maintained an increasing trend in the BU/hPMSC group, while MDA and LDH showed a declining trend. hPMSCs promoted autophagy in a mouse model of busulfan-induced testicular toxicity To further confirm the relationship between autophagy and spermatogenesis, fluorescence microscopy was used to investigate the colocalization of autophagy-associated proteins, including p62 and LC3.

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Moreover, the mRNA levels of apoptotic genes such as γ-H2AX, BRCA1, and PARP1 revealed a decreasing trend in the BU/hPMSC group compared with the BU group (Fig. 4 d). hPMSCs increased oxidative protection and decreased oxidative damage in a mouse model of busulfan-induced testicular toxicity We next sought to verify whether hPMSCs protect against oxidative stress and decrease oxidative damage in the busulfan-induced testis toxicity mouse model.

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