Does the beta regularization parameter of bayesian penalized likelihood reconstruction always affect the quantification accuracy and image quality of positron emission tomography computed tomography?

In addition, highly significant negative correlations were observed between SUVs and beta values for both lesion‐size groups before the PVC ( P < 0.001 for all).

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reported that, for small pulmonary nodules, a decreasing trend was observed in SUVmax when beta value increased from 150 to 350 ( P < 0.01), although they did not state whether PVC was performed and no further information on SUVmean, SUVpeak, and lesion sizes was found. 21 After PVC was performed, SUVmean and SUVmax of both groups showed negative correlations.

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This suggests that the drawback of increasing beta values on quantification accuracy may not be significant for sub‐centimeter lesions when PVC is performed and SUVpeak is chosen as the quantification parameter.

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