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Phenotypic and Functional Analyses Guiding Combination Immune Checkpoint Immunotherapeutic Strategies in HTLV-1 Infection.

Front Immunol · 2021 · PMC7985073 · PMID 33767694

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markedly significantno p-value reported
Except for several individuals in the single PD-L1 and triple blockade groups, both single and combination blockade strategies resulted in a markedly significant decrease in IL-2 + CD8 T cell responses.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.