Could Altered Evoked Pain Responsiveness Be a Phenotypic Biomarker for Alzheimer's Disease Risk? A Cross-Sectional Analysis of Cognitively Healthy Individuals.

J Alzheimers Dis · 2021 · PMC7990440 · PMID 33337380

Europe PMC DOI

hedged sentence

0.0900

closest p · 1.8× alpha

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boldest claim

The sentences

marginally significantp < 0.09so close (0.05 < p ≤ 0.1)

A follow-up analysis examining the effects of APOE4 on pain unpleasantness adjusting for differences in stimulus intensity at each percept level across genetic groups indicated that the pattern of results was little changed, with the APOE4 main effect becoming marginally significant ( p < 0.09) but the overall effect size increasing slightly (from d = 0.26 to d = 0.33).

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