It is highly significant that miR-125b , the most predominant parasite miRNA found in host macrophages of mice infected with F. hepatica , is conserved amongst the trematode clade of helminths, including the blood flukes of the genus Schistosoma , as it points towards a common mechanism for the anti-inflammatory control amongst these important parasites of humans and their livestock.
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Fasciola hepatica hijacks host macrophage miRNA machinery to modulate early innate immune responses.
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