Human Osteochondral Explants: Reliable Biomimetic Models to Investigate Disease Mechanisms and Develop Personalized Treatments for Osteoarthritis.

Upregulation of EPAS1 was highly significant in response to IL-1β, 65% MS and T3 treatment (FC = 4.6; P = 3.6 × 10 –2 , FC = 1.8; P = 1.8 × 10 –20 and FC = 1.8; P = 1.0 × 10 –3 , respectively Fig. 1 ).

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