Transcriptome analyses of 7-day-old zebrafish larvae possessing a familial Alzheimer's disease-like mutation in psen1 indicate effects on oxidative phosphorylation, ECM and MCM functions, and iron homeostasis.

BMC Genomics · 2021 · PMC7992352 · PMID 33761877

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MCM complex dysregulation may drive DNA replication stress Comparison of the transcriptomes of pools of 7 dpf heterozygous psen1 Q96_K97del mutant larvae to their wild type siblings revealed highly significant regulatory effects on genes involved with DNA replication and the cell cycle.

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