Implications of Polymorphisms in the BCKDK and GATA-4 Gene Regions on Stable Warfarin Dose in African Americans.

21 Although we observed a marginally significant association between the GATA‐4 rs2645400 SNP and warfarin dose in the subpopulation of CYP2C9*1 allele homozygotes on multiple linear regression, it was no longer associated after adjusting for CYP2C rs12777823, a SNP associated with warfarin clearance and dose requirements in African ancestry patients. 8 It is possible that the lower frequency of the SNP in African Americans vs.

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