non-Tg littermate mice, revealed some level of heterogenicity amongst the two Tg lines ( Figure 3C ; Supplementary Table 3 ); yet a notable trend for several metabolic genes downregulation was found in the muscle and pancreas (most evident in the Tgl178 line) tissues.
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Clusterin overexpression in mice exacerbates diabetic phenotypes but suppresses tumor progression in a mouse melanoma model.
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