Transient changes in white matter microstructure during general anesthesia.

These transient changes were highly significant and were detected diffusely throughout the brain white matter regions using both a voxel-wise technique (TBSS) ( Fig 1 ) as well as regions of interest approaches (the Johns Hopkins Atlas ROIs) ( Fig 2 and Tables 1 and 4 ).

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The volumetric results ( Table 6 ) that showed increased CSF volume and an overall trend in increased ventricular size may corroborate this interpretation.

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