CRISPR/Cas9-Mediated Genome Editing in Comfrey (<i>Symphytum officinale</i>) Hairy Roots Results in the Complete Eradication of Pyrrolizidine Alkaloids.

The reduction in both the predicted downregulated and knock-out lines was highly significant ( p < 0.0001) supporting the predictions of the gene-editing effects on the hss gene in Table 1 .

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