Testosterone in Female Depression: A Meta-Analysis and Mendelian Randomization Study.

Biomolecules · 2021 · PMC7999217 · PMID 33802106

Europe PMC DOI

hedged sentences

0.5000

closest p · 10.0× alpha

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boldest claim

The sentences

borderline significantp = 0.5not close (p > 0.1)

The results showed that testosterone levels were decreased (borderline significant) in postmenopausal depression patients compared with healthy controls (Z = 1.92, p = 0.5), while between-study heterogeneity was totally absent ( I 2 = 0%, and p = 0.05) ( Figure 4 ).

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borderline significanceno p-value reported

Our meta-analysis shows a significant association between absolute serum testosterone levels and female depression, which remains true for the premenopausal group while achieving borderline significance in the postmenopausal group.

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