a trend towards significancep = 0.057
Longitudinal Changes in Plasma Aβ Concentrations Employing the Ultrasensitive Simoa Technology Longitudinal analyses revealed that Aβ1-40 concentrations decreased over time (T1 to T2) with a trend towards significance ( p = 0.057), before adjusting for covariates, age, sex and APOE ε4 genotype, wherein pairwise comparisons showed significantly decreased mean plasma Aβ1-40 concentrations in MCs ( p = 0.045, Table 3 ).