Exon Shuffling Played a Decisive Role in the Evolution of the Genetic Toolkit for the Multicellular Body Plan of Metazoa.

Genes (Basel) · 2021 · PMC8001218 · PMID 33800339

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highly significantno p-value reported

Analysis of the exon–intron structures of thousands of human genes has indeed revealed that there is a statistically highly significant excess of phase 1 introns in the vicinity of the signal peptide cleavage sites of secreted proteins [ 78 ].

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