Determination of Pharmacokinetic and Pharmacokinetic-Pharmacodynamic Parameters of Doxycycline against <i>Edwardsiella ictaluri</i> in Yellow Catfish (<i>Pelteobagrus fulvidraco</i>).

Antibiotics (Basel) · 2021 · PMC8004065 · PMID 33800996

Europe PMC DOI

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a decreasing trendno p-value reported

After receiving the same dose with disparate time intervals from 96 to 12 h, the AUC 0–96h /MIC was distinctly increased in plasma and tissues, but the %T > MIC had a decreasing trend.

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an increasing trendno p-value reported

In addition to the increase of oral dose, the C max also presented an increasing trend in all tissues except in liver.

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