Tetramethylpyrazine Improves Cognitive Impairment and Modifies the Hippocampal Proteome in Two Mouse Models of Alzheimer's Disease.

Cluster 2 mainly showed the proteins with a decreasing trend of TMP administration, the BP of these proteins included the negative regulation of hydrogen peroxide catabolic process, transport, positive regulation of catalytic activity of potassium ion transport, negative regulation of oxidoreductase activity, be organization, and protein complex assembly.

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In 3xTg mice, Cluster 1 showed the proteins with an increasing trend of TMP administration, and the BP of these proteins included transport, negative regulation of mitochondrial membrane potential, hepatocyte apoptotic process, and ion transport.

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