Finally, there was significantly lower reduction in the mean change in IA2A from 6 to 12 months in the probiotic group compared with the placebo group (p=0.004), and lower decline in GADA in the probiotic groups at 6–12 months, although of borderline significance (p=0.051).
One recent randomized controlled trial in 44 Iranian children with T1D found that the supplementation with a synbiotic ( Lactobacillus sporogenesis GBI-30 and fructooligosaccharides) for 8 weeks resulted in a significant decrease in the HbA1c and marginally significant decrease in fasting blood glucose. 23 Strengths and limitations The strengths of this study include adequate randomisation, allocation concealment and intention-to-treat analysis.