Replicating bacterium-vectored vaccine expressing SARS-CoV-2 Membrane and Nucleocapsid proteins protects against severe COVID-19-like disease in hamsters.

Differences in serum anti-N IgG titers between hamsters immunized with the MN vaccine, alone or in combination with S protein vaccines, and sham- or vector-immunized hamsters were highly significant at both Week 3 and Week 8 ( P < 0.0001) (Fig. 7d ).

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