Complete remission of metastatic osteosarcoma using combined modality therapy: a retrospective analysis of unselected patients in China.

[ 6 , 7 , 15 ] conducted a series of studies that revealed the prognosis for high-grade osteosarcoma of the extremities metastatic to the lung, with a 5-year EFS rate of 36% for patients with localized disease who later relapsed and 9% for patients with resectable lung metastases at presentation; the difference was highly significant ( P < 0.0001).

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