Barely Significant
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Impact of initial vancomycin pharmacokinetic/pharmacodynamic parameters on the clinical and microbiological outcomes of methicillin-resistant Staphylococcus aureus bacteremia in children.

PLoS One · 2021 · PMC8016336 · PMID 33793589

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an increasing trendno p-value reported
aureus isolates with MIC 1 μg/mL or greater than 1 μg/mL, which was determined by MicroScan WalkAway showed an increasing trend.

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a decreasing trendno p-value reported
Line 193-195, During the study period, the proportion of MRSA isolates with vancomycin MIC � 0.5 μg/mL showed a decreasing trend; 30.8% (2010-2012), 3.3% (2013–2015), and 5.9% (2016–2018) (P for trend =0.246).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.