Analysis of morphological and neurochemical changes in subthalamic nucleus neurons in response to a unilateral 6-OHDA lesion of the substantia nigra in adult rats.

Sidak’s multiple comparison test revealed a highly significant difference between the neuronal cross-sectional area of STN neurons in control rats and those ipsilateral to the lesion at 5 months (P = 0.0046), and a more moderate difference at 1 month post-lesion (P = 0.0443), suggesting that the cross-sectional area of STN neurons is reduced between 1- and 5-months post-lesion.

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