Epithelial miR-141 regulates IL-13-induced airway mucus production.

Furthermore, MUC5AC gene expression in whole lung homogenate displayed a decreasing trend in mice that received mmu-miR-141-3p antagomir ( Figure 8F ), and the goblet cell–specific gene CLCA1 was significantly downregulated upon mmu-miR-141-3p antagomir treatment in allergen-challenged lungs ( Figure 8G ), suggesting that mmu-miR-141-3p inhibition blocked allergen-induced goblet cell differentiation.

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